CONTEXT A common genetic variant near PPP1R3B (rs4841132G>A) has been associated with increased hepatic computed tomography (CT) attenuation, and with plasma levels of glucose and liver enzymes. OBJECTIVE To elucidate the association of rs4841132 with hepatic CT attenuation, and to test if synergistic effects modify the association of the variant…[Leer más]

Significant scale-up was realized with the CM line by increasing the throughput rate to 10 kg/h. The manufactured granules yielded very similar results to the previous small-scale granulation runs. API homogeneity was demonstrated (RSD less then 2%) with Blend Uniformity Analysis (BUA). The efficiency of TSWG granulation was compared to High-Shear…[Leer más]