Objective Endovascular intervention in uncomplicated type B dissection has not been shown conclusively to confer benefit on patients. The hemodynamic effect of primary entry tear coverage is not known. Endovascular stent grafts were deployed in a model of aortic dissection with multiple fenestrations to study these effects. It is hypothesized that endograft deployment will lead to restoration of parabolic true lumen flow as well as elimination of false lumen flow and transluminal jets and vortices locally while maintaining distal false lumen canalization. Methods Thoracic stent grafts were placed in silicone models of aortic dissection with a compliant and mobile intimal flap and installed in a flow loop. Pulsatile fluid flow was established with a custom positive displacement pump, and the models were imaged by four-dimensional flow magnetic resonance imaging. Full flow fields were acquired in the models, and velocities were extracted to calculate flow rates, reverse flow indices, and oscillatory shear indexancing endovascular intervention beyond sole entry tear coverage to prevent further false lumen canalization through uncovered fenestrations.Objective The aim of this in vitro study was to test the effect of different composite modulation protocols (pre-heating, light-curing time and oligomer addition) for bulk filling techniques on resin polymerization stress, intra-pulpal temperature change and degree of conversion. Methods Class I cavities (4mm depth×5mm diameter) were prepared in 48 extracted third molars and divided in 6 groups. Restorations were completed with a single increment, according to the following groups (1) Filtek Z250XT (room temperature – activated for 20s); (2) Filtek Z250XT (at room temperature – activated for 40s); (3) Filtek Z250XT (pre-heated at 68°C – activated for 20s); (4) Filtek Z250XT (pre-heated at 68°C – activated for 40s); (5) Filtek BulkFill (at room temperature – activated for 20s); (6) Filtek Z250XT (modified by the addition of a thio-urethane oligomer at room temperature – activated for 40s). Acoustic emission test was used as a real-time polymerization stress (PS) assessment. The intra-pulpal temperature change was recorded with a thermocouple and bottom/top degree of conversion (DC) measured by Raman spectroscopy. Data were analyzed with one-way ANOVA/Tukey’s test (α=5%). Results Pre-heating the resin composite did not influence the intra-pulpal temperature (p=0.077). The thio-urethane-containing composite exhibited significantly less PS, due to a lower number of acoustic events. Groups with pre-heated composites did not result in significantly different PS. Filtek BulkFill and the thio-urethane experimental composite presented significantly higher DC. Significance Resin composite pre-heating was not able to reduce polymerization stress in direct restorations. However, thio-urethane addition to a resin composite could reduce the polymerization stress while improving the DC.Objective The purpose of this study was to compare the acute histological effects of MicroPulse transscleral cyclophotocoagulation (MPCPC) using the MicroPulse P3 Device and continuous wave transscleral cyclophotocoagulation (CWCPC) on the ciliary body and adjacent structures in human cadaver eyes. Methods Quadrants of 6 human cadaver eyes from 3 different donors were subjected to traditional CWCPC, slow burn CWCPC, MPCPC, or no treatment (internal control). Sutures were used to differentiate different treatment areas on each eye. selleckchem Differential inking was applied after treatments to aid in microscopic correlation. All specimens were subject to standard histologic processing. Tissue sections were cut at 4 microns and stained with hematoxylin and eosin according to established protocols. Pathologic evaluation by light microscopy was confirmed by a senior pathologist blinded to treatment groups. Results In all 6 eyes, tissues treated with traditional and low burn CWCPC showed variable coagulative tissue damage to the ciliary body compared with untreated tissues. Minimal histologic changes were identified within the ciliary processes, although variable pigment clumping and streaming were noted within the pigmented ciliary epithelium. In contrast to CWCPC, MPCPC-treated tissues showed only minimal coagulative tissue damage to the ciliary body. Variable pigment clumping and streaming, however, were also noted in the pigmented ciliary epithelium in MPCPC-treated tissues. Conclusions In human cadaver eyes, MPCPC treatment caused less tissue disruption to the ciliary body compared with traditional and low burn CWCPC treatments. MPCPC may be a less destructive and more selective method of cyclophotocoagulation when compared with traditional and low burn CWCPC.Feed-water valves are widely used in nuclear power plants to regulate the flow rate of the water supplying to steam generators and thus hold the water level in steam generators at desired value. The flow rate characteristics of feed-water valves have important effects on the management quality of the water level in steam generators and therefore influence the safety and the efficiency of nuclear power plants. In this paper, the effects of throttling window shapes on the flow rate characteristics through feed-water valves are investigated in two aspects, i.e., the overall performances and the fluid dynamics. First of all, a dimensionless parameter defining throttling window shapes is proposed for quantitative assessment. Then, for the analysis of overall performances, the rated flow coefficient, the loss coefficient, and the inherent valve characteristics are investigated. A revised fitting function is obtained to predict the inherent valve characteristics with different throttling window shapes for engineering application. Finally, for the observation of fluid dynamics, the velocity characteristics and the pressure characteristics are both discussed. The wear conditions are predicted at different relative travel and throttling window shapes. This paper provides a reference for researchers dealing with the design work of feed-water valves and is beneficial for the improvement of the whole water level control system.