Integrated-type proton computed tomography (pCT) measures proton stopping power ratio (SPR) images for proton therapy treatment planning, but its image quality is degraded due to noise and scatter. Although several correction methods have been proposed, techniques that include estimation of uncertainty are limited. This study proposes a novel uncertainty-aware pCT image correction method using a Bayesian convolutional neural network (BCNN). A DenseNet-based BCNN was constructed to predict both a corrected SPR image and its uncertainty from a noisy SPR image. A total 432 noisy SPR images of 6 non-anthropomorphic and 3 head phantoms were collected with Monte Carlo simulations, while true noise-free images were calculated with known geometric and chemical components. Heteroscedastic loss and deep ensemble techniques were performed to estimate aleatoric and epistemic uncertainties by training 25 unique BCNN models. 200-epoch end-to-end training was performed for each model independently. Feasibility of the predicge margin criterion, toward elaboration of uncertainty-guided proton therapy.Evidence suggests that nicotine intake promotes atherosclerosis. Anisomycin We enrolled 100 patients with coronary heart disease (CHD) and found that plaque burden, TXNIP expression, and inflammatory chemokine levels were higher in smokers than non-smokers. Additionally, patients with higher TXNIP expression in peripheral blood mononuclear cells (PBMCs) had a higher Gensini Scores and higher plasma IL-1β and IL-18 levels. Treating bone marrow-derived macrophages (BMDMs) with nicotine in vitro led to enhanced lipid phagocytosis, chemotaxis, and increased production of reactive oxygen species (ROS), which activated TXNIP/NLRP3 inflammasome signaling and promoted pyroptosis, as evidenced by caspase-1 cleavage and increased production of IL-1β, IL-18, and gasdermin D. Nicotine intake by ApoE(-/-) mice fed a high-fat diet recapitulated those phenotypes. The effects of nicotine on pyroptotic signaling were reversed by N-acetyl-cysteine, a ROS scavenger. Silencing TXNIP in vivo reversed the effects of nicotine on macrophage invasion and vascular injury. Nicotine also induced pyroptotic macrophages that contributed to the apoptotic death of endothelial cells. These findings suggest that nicotine accelerates atherosclerosis in part by promoting macrophage pyroptosis and endothelial damage. Therefore, targeting the TXNIP/NLRP3-mediated pyroptotic pathway in macrophages may ameliorate nicotine-induced endothelial damage.

The objectives of the present study were (1)to analyze the internal and external load profile of training and competition carried out by semiprofessional football players during a 27-week period and (2)to examine the possible link between this type of periodization and players’ fitness status and their readiness to compete.

Training and match data were obtained from 26 semiprofessional football players belonging to the reserve squad of a Spanish La Liga club during the 2018/19 season. For the purpose of this study, the distribution of external and internal load during a typical training microcycle, with 6 or 7 days between matches, was analyzed. Five types of sessions were considered strength, duration, velocity, preofficial match, and official match.

The results showed a different internal and external load profile for each type of session, with the load being consistently higher during matches when compared with training sessions (28.9%-94% higher), showing significant differences in all the variables. There was a clear tapering strategy in the last days of the week to arrive with enough freshness to compete, shown by the decrease of the values in the 2 days before the match (15%-83% reduction, depending on the variable). Furthermore, the horizontal alternation of the load allowed the players to maintain their fitness level during the 27-week period.

Our findings suggest that this weekly periodization approach could help achieve a double conditional target, allowing a short tapering strategy to face the match with enough freshness and serving as a strategy for maintaining or optimizing players’ physical performance during the season.

Our findings suggest that this weekly periodization approach could help achieve a double conditional target, allowing a short tapering strategy to face the match with enough freshness and serving as a strategy for maintaining or optimizing players’ physical performance during the season.The present study examined the effects of daily activities of the hands on finger motor function in older adults. Maximum tapping frequency with each finger during single-finger tapping and alternate movements of index-middle, middle-ring, and ring-little finger pairs during double-finger tapping were compared between older adults who used their hands actively in their daily lives and those who did not. The active participants had significantly faster tapping rates for the ring finger in the single-finger tapping and the middle-ring finger pair in the double-finger tapping than did the inactive participants. Thus, daily activity of the hands in older adults could be effective at preventing the loss of dynamic motor function in individual fingers, especially with greater difficulty in movement, resulting from the degeneration with age.

Women’s professional cycling has grown in popularity, and this increase is also apparent in Brazil, which has increased its female cycling calendar in recent years. The aim of this observational study was to (1)determine training and competition loads of a top-level Brazilian female cycling team, (2)evaluate nutrition and clinical health, and (3)measure whether exercise capacity changed throughout the season.

Training and competition data were collected over the season using global positioning system monitors, while laboratory-based physiological and performance measures (incremental cycling test, 30-s Wingate, 4-km time trial) and clinical and nutritional analyses were performed at time points throughout the season.

Total distance covered over the year was 11,124 (2895)km (7382-14,698km). Endurance capacity was reduced over the season (P = .005) but not anaerobic power (all P > .05). Nutrition and stress markers remained largely unchanged throughout the season, although there were some individual fluctuations in some measures, and testosterone concentration was low for some.