Pregnancy-related hormones may stimulate thyroid cancer growth, but whether pregnancy affects the prognoses of patients with lung metastases from differentiated thyroid cancer (DTC-LM) after surgery and radioiodine therapy is unclear.

To assess the impact of pregnancy on DTC-LM through the comparison of prognoses between female patients with DTC-LM who did and did not become pregnant after surgery and radioiodine therapy.

We retrospectively analyzed the records of 124 female patients aged 16-35 years who underwent surgery and radioiodine therapy for DTC-LM. These patients were divided into pregnancy group (n=37) and non-pregnancy group (n=87) according to whether they became pregnant after surgery and radioiodine therapy, regardless of whether they had a pregnant history before treatment.

The 5- and 10-years PFS rates were 94.52% and 63.22% in pregnancy group versus 89.82% and 58.13% in non-pregnancy group. The 5- and 10-years cumulative OS rates of pregnancy group is 97.30% and 85.77% versus 93.50% and 81.95% in non-pregnancy group (all P>0.05). The median time of follow-up in the pregnancy and non-pregnancy group was 82 months (25-136 months) and 68 months (13-133 months), respectively. Non- 131I-avid LM and primary tumors needing repeated resection were independent predictors of poor PFS for patients in pregnancy group.

Pregnancy does not affect the prognoses of patients with DTC-LM after surgery and radioiodine therapy. Non- 131I avid LM and repeated primary tumor surgeries are independent risk factors for poor prognoses of pregnant patients.

Pregnancy does not affect the prognoses of patients with DTC-LM after surgery and radioiodine therapy. Non- 131I avid LM and repeated primary tumor surgeries are independent risk factors for poor prognoses of pregnant patients.

Side effect warnings can contribute directly to their occurrence via the nocebo effect. This creates a challenge for clinicians and researchers, because warnings are necessary for informed consent, but can cause harm. SB203580 Positive framing has been proposed as a method for reducing nocebo side effects whilst maintaining the principles of informed consent, but the limited available empirical data are mixed.

To test whether positive attribute framing reduces nocebo side effects relative to negative framing, general warning, and no warning.

Ninety-nine healthy volunteers were recruited under the guise of a study on virtual reality (VR) and spatial awareness. Participants were randomized to receive positively framed («7 out of 10 people will not experience nausea»), negatively framed («3 out of 10 people will experience nausea»), general («a proportion of people will experience nausea»), or no side effect warnings prior to VR exposure.

Receiving a side effect warning increased VR cybersickness relative to no warning overall, confirming that warnings can induce nocebo side effects. Importantly, however, positive framing reduced cybersickness relative to both negative framing and the general warning, with no difference between the latter two. Further, there was no difference in side effects between positive framing and no warning.

These findings suggest that positive framing not only reduces nocebo side effects relative to negative framing and general warnings, but actually prevents nocebo side effects from occurring at all. As such, positive attribute framing may be a cheap and ethical way to reduce nocebo side effects.

These findings suggest that positive framing not only reduces nocebo side effects relative to negative framing and general warnings, but actually prevents nocebo side effects from occurring at all. As such, positive attribute framing may be a cheap and ethical way to reduce nocebo side effects.

Camouflage of nasal dorsum, aesthetic augmentation, and highlighting the dorsal aesthetic lines are essential elements in modern rhinoplasty. Numerous techniques have been utilized, including deep temporal fascia, rectus abdominis fascia, and diced cartilage in fascia (DC-F). Despite their widespread adoption, technical challenges remain, especially when utilized for aesthetic purposes.

This paper details the utilization of fascia and DC-F for aesthetic dorsal refinement in primary and secondary cases. One of the main goals was to achieve ideal dorsal aesthetic dorsal lines rather than just volume augmentation.

The authors employed grafts from the deep temporalis fascia and rectus abdominis fascia in 4 configurations (1) single layer, (2) double layer, (3) full-length DC-F, and (4) partially filled segmental DC-F grafts. Technical refinements included careful determination of dimensions and meticulously suturing to the dorsum at appropriately 10 points to prevent graft displacement.

The authors reportnd minimizes problems.

Face-to-face tobacco cessation has had limited reach and efficacy in Alaska Native (AN) communities. We describe our two-phased approach to develop content for Connecting Alaska Native People to Quit Smoking, a Facebook group intervention to reduce barriers to evidence-based smoking cessation treatment for AN people in Alaska.

Phase 1 included semi-structured telephone interviews with 30 AN people who smoke and ten stakeholders. They provided feedback on existing content from the Centers for Disease Control and Prevention Tips campaign and AN digital stories. Phase 2 included an online survey with a new group of 40 AN smokers who provided feedback on existing content via a measure of perceived effectiveness and cultural relevance.

Phase I results revealed participants evaluated content based upon story strength, relevance to AN culture, emotional appeal, relatability to AN people, and favorite video. No single posting was rated highly across all themes. All perceived effectiveness (PE) and cultural relevance median scores fell between 3.5 and 4.4 (range 1-5). PE scores varied across participant demographic groups.

Content embodying characteristics perceived to be most appealing, effective, and culturally relevant were selected for the private Facebook group content library with refinements made to incorporate images of AN people engaged in AN activities. PE scores indicate a need for a wide variety of content that moderators could pull from when conducting the intervention.

Social media content targeting specific population sectors, such as American Indian/AN people for tobacco cessation needs to be culturally tailored. Our approach provides a model others can follow to determine what is appealing, relevant, and effective messaging.

NCT03645941.

NCT03645941.